Premium
Malignant fibrous histiocytoma of the lung
Author(s) -
McDonnell Timothy,
Kyriakos Michael,
Mazoujian Gwen,
Roper Charles
Publication year - 1988
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19880101)61:1<137::aid-cncr2820610124>3.0.co;2-w
Subject(s) - desmin , vimentin , medicine , pathology , cytokeratin , immunostaining , histiocyte , lung , immunohistochemistry , sarcoma , soft tissue
Malignant fibrous histiocytoma (MFH) is among the most common soft tissue sarcomas of adult life, but rarely occurs elsewhere. We report an example of primary MFH of the lung and review 15 previously reported acceptable cases with current follow‐up information. Histologically, the tumor in our case was pleomorphic with storiform and fascicular areas. Tumor cells showed positive immunostaining for alpha 1 ‐antitrypsin, alpha 1 ‐antichymotrypsin, and vimentin. Stains for desmin, cytokeratin, myoglobin, epithelial membrane antigen, S‐100 protein, and lysozyme were negative. Electron microscopic study showed histiocyte‐like, fibroblast‐like, intermediate, and undifferentiated tumor cells. A variety of methods were used to treat these patients. Two patients survived for 5 or more years, two were alive and well at 8 and 12 months, respectively, two were alive with metastatic tumor at 3 and 18 months, respectively, and ten patients died of tumor, with an average survival of 1 year.