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Barrett's esophagus in three children after antileukemia chemotherapy
Author(s) -
Dahms Beverly Barrett,
Greco M. Alba,
Strandjord Sarah E.,
Rothstein Fred C.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871215)60:12<2896::aid-cncr2820601208>3.0.co;2-p
Subject(s) - medicine , esophagus , chemotherapy , gastroenterology , esophagitis , leukemia , metaplasia , reflux esophagitis , disease , reflux
Barrett's esophagus, a columnar metaplasia of the lower esophagus that is usually associated with gastroesophageal reflux (GER), was found in three children on long‐term antileukemia chemotherapy. Two of the children had been on a standard acute lymphoblastic leukemia (ALL) maintenance protocol with 2 to 3 years of methotrexate and 6‐mercaptopurine administration. The third child received daunorubicin, cytosine arabinoside, and 6‐thioguanine for treatment of acute myelogenous leukemia (AML). None of the patients had clinical or pathologic evidence of GER disease. We propose that the Barrett's esophagus in these patie0ts did not result from the usual peptic esophagitis, but rather from chemotherapy‐induced esophageal mucosal injury.