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The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis
Author(s) -
Klein Walter A.,
Miller Helen H.,
Anderson Margaret,
Decosse Jerome J.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871215)60:12<2863::aid-cncr2820601202>3.0.co;2-i
Subject(s) - sulindac , medicine , tamoxifen , familial adenomatous polyposis , computed tomographic , fibromatosis , radiology , physical examination , cancer , surgery , colorectal cancer , computed tomography , breast cancer , nonsteroidal
Seven familial polyposis patients with desmoid tumors were treated with indomethacin, sulindac, or tamoxifen either as single agents or in combination. Serial computed tomographic (CT) scan examination was employed for objective measurement of tumor size since physical examination alone was an inaccurate means to evaluate intraabdominal and retroperitoneal desmoids. Only one patient with minimal tumor burden demonstrated a favorable response with complete resolution of an abdominal wall desmoid.