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Ectopic prolactin secretion from a gonadoblastoma
Author(s) -
Hoffman William H.,
Gala Richard R.,
Kovacs Kalman,
Subramanian Marappa G.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871201)60:11<2690::aid-cncr2820601119>3.0.co;2-j
Subject(s) - medicine , secretion , prolactin , gonadoblastoma , hormone , genetics , biology , karyotype , chromosome , gene
A 6.5‐year‐old girl developed isosexual, pseudoprecocious puberty secondary to a gonadoblastoma. The tumor was found to produce and secrete both immunoassayable and boiassayable prolactin based on immunohistochemical techniques and the presence of a prolactin gradient between the tumor vein and peripheral vein. The source of the prolactin was a Sertoli‐like cell. Neither growth hormone nor growth hormone‐releasing hormone was detected within the tumor. This case confirms the ectopic production of prolactin by neoplastic tissue.