Premium
Abnormalities of protooncogenes in non‐small cell lung cancer. Correlations with tumor type and clinical characteristics
Author(s) -
Cline Martin J.,
Battifora Hector
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871201)60:11<2669::aid-cncr2820601116>3.0.co;2-4
Subject(s) - cancer research , lung cancer , cancer , pathology , biology , lung , medicine
Twenty‐seven primary non‐small cell (NSC) lung cancers were analyzed for alterations of protooncogenes by DNA hybridization techniques. Abnormalities were found in 56% of tumors including ten of 16 adenocarcinomas, three of nine squamous cell cancers and two of two larger cell cancers. Five protooncogenes were found to be commonly altered in tumors at frequencies between 12% and 60%. These were c‐myc , c‐myb , c‐ras‐Ha , c‐erbB‐1 and c‐erb‐B‐2. Alterations in c‐erbB‐1 and c‐erbB‐2 correlated with histologic type of tumor and were more common in advanced cancers. Allelic deletions of c‐ras‐Ha or c‐myb were frequently observed in primary tumors which recurred or progressed after surgery (five of six). Analysis of protooncogenes may provide insights into the pathogenesis of lung cancer and may aid in predicting clinical behavior.