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Acute megakaryocytic leukemia. Flow cytometric analysis of DNA content at diagnosis and during the course of therapy
Author(s) -
Pantazis Cooley G.,
Allsbrook William C.,
Ades Edwin,
Houston James,
Brubaker Leonard H.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871115)60:10<2443::aid-cncr2820601016>3.0.co;2-s
Subject(s) - medicine , flow cytometry , bone marrow , acute leukemia , leukemia , pathology , dna , minimal residual disease , cell cycle , immunology , cancer , biology , genetics
Flow cytometry (FCM) for the determination of DNA content and cell cycle analysis was performed on multiple bone marrows from a case of acute megakaryocytic leukemia in a 71‐year‐old woman. Two aneuploid (multiploid) peaks were present at diagnosis. This multiploidy was a stable characteristic when studied temporally. The disappearance of the peaks in the bone marrow specimens directly correlated with complete remission morphologically. These findings further support the concept of FCM as an adjunct to morphologic study in identifying residual tumor burden.