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Familial colon cancer in the Tel‐Aviv area and the influence of ethnic origin
Author(s) -
Rozen Paul,
Lynch Henry T.,
Figer Arie,
Rozen Shulamit,
Fireman Zvi,
Legum Cyril,
Katz Leah,
Moy Alan,
Kimberling William,
Lynch Jane,
Watson Patrice
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871101)60:9<2355::aid-cncr2820600940>3.0.co;2-r
Subject(s) - colorectal cancer , medicine , cancer , family history , family aggregation , tel aviv , ethnic group , relative risk , first degree relatives , oncology , demography , disease , confidence interval , sociology , anthropology , library science , computer science
The family history of colon cancer was investigated in 38,823 individuals (2,129 families) who comprised a control and an oncology patient series from Tel‐Aviv and nearby areas. A significant increased risk for colon cancer was observed among first‐degree relatives of colon cancer patients when compared to controls. When the patient sample was divided into two groups based on country and continent of birth—European (Ashkenazim) and other (non Ashkenazim)—the relatives of the nonAshkenazi subjects showed a greater relative risk for colon cancer ( P < 0.05). Colon cancer was found to be less frequent in nonAshkenazim than in Ashkenazim controls. These findings suggest that although the colon cancer frequency in the nonAshkenazi group is lower, the genetic component may be more important than for the Ashkenazi sample. The nonAshkenazi Jews may represent distinct subgroups that differ with respect to either primary genetic susceptibility to colorectal cancer and/or they may have been subjected to peculiar, environmental carcinogenic exposures when compared to their Ash‐kenazim brethren.