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Neuroendocrine features in poorly differentiated and undifferentiated carcinomas of the cervix
Author(s) -
Barrett Rolland J.,
Davos Irene,
Leuchter Ronald S.,
Lagasse Leo D.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871101)60:9<2325::aid-cncr2820600935>3.0.co;2-g
Subject(s) - adenosquamous carcinoma , neuroendocrine differentiation , pathology , cervix , adenocarcinoma , medicine , carcinoma , pathological , clear cell carcinoma , neoplasm , cancer , prostate cancer
Neuroendocrine or argyrophil cell carinoma of the cervix has recently been accepted as a distinct clinical‐pathological entity. The histologic pattern of these carcinomas is usually poorly differentiated or undifferentiated. Twenty patients with a histologic diagnosis of small cell carcinoma, undifferentiated carcinoma, poorly differentiated adenocarcinoma, or poorly differentiated, adenosquamous carcinoma of the cervix were evaluated for neuroendocrine features. The results of studies to detect neurosecretory granules were positive in seven of the 20 cases. Not only small cell carcinomas, but also tumors classified as undifferentiated carcinoma and poorly differentiated, adenosquamous carcinoma contained cytoplasmic granules consistent with neuroendocrine carcinoma of the cervix. The prognosis for survival appears poorer for patients having tumors with neurosecretory granules after controlling for stage and histologic grade of the neoplasm.