Premium
Lymphoma with clonal T‐cell receptor gene rearrangement in a 25‐year survivor of Hodgkin's disease
Author(s) -
Li Frederick P.,
Gimbrere Kathreen,
Ritz Jerome,
Saito Haruo,
Longtine Janina A.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871101)60:9<2213::aid-cncr2820600918>3.0.co;2-j
Subject(s) - lymphoma , gene rearrangement , medicine , biopsy , pathology , lymph node biopsy , disease , lymph node , cancer research , gene , biology , genetics
A woman was treated for Hodgkin's disease, remained disease‐free for 25 years, and then developed waxing and waning adenopathy during the next 2 years. The histologic examination of a lymph node biopsy specimen showed a T‐cell non‐Hodgkin's lymphoma. The patient's indolent clinical course prompted a second biopsy to obtain tissue for T‐cell receptor gene rearrangement studies. A southern blot analysis using a human T‐cell receptor beta chain probe showed a new band of rearranged DNA, which confirmed the diagnosis of T‐cell lymphoma.