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The development of lhermitte's sign during cisplatin chemotherapy: Possible drug‐induced toxicity causing spinal cord demyelination
Author(s) -
Walther Philip J.,
Jr Eugene Rossitch,
Bullard Dennis E.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871101)60:9<2170::aid-cncr2820600909>3.0.co;2-n
Subject(s) - medicine , cisplatin , ototoxicity , spinal cord , peripheral neuropathy , central nervous system , toxicity , chemotherapy , peripheral , peripheral nervous system , neurotoxicity , multiple sclerosis , pathology , anesthesia , surgery , immunology , endocrinology , psychiatry , diabetes mellitus
Cisplatin is a recognized neurotoxic agent that commonly causes ototoxicity and peripheral neuropathy. In conjunction with characteristic peripheral neuropathy, two patients treated with high‐dose cisplatin developed Lhermitte's sign, a manifestation of posterior column spinal cord pathology. After cisplatin therapy was stopped, this symptom gradually resolved. This suggests that at high doses cisplatin may also cause demyelinating central nervous system lesions involving the spinal cord.