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Failure of adjuvant chemotherapy in testicular cancer
Author(s) -
Bernstein Joel I.,
Freiha Fuad,
Breeden James,
Torti Frank M.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871015)60:8<1729::aid-cncr2820600807>3.0.co;2-l
Subject(s) - medicine , etoposide , bleomycin , vinblastine , retroperitoneal lymph node dissection , germ cell tumors , testicular cancer , cisplatin , chemotherapy , lymph node , surgery , oncology
Two cases of failure of adjuvant chemotherapy after retroperitoneal lymph node dissection of Stage II nonseminomatous germ cell tumors are described. In both cases, initial surgical resection was complete, and two cycles of chemotherapy with cisplatin, vinblastine, and bleomycin were administered in an appropriate dose and schedule. Although one patient remains without evidence of disease 12 months after initiation of salvage chemotherapy with cisplatin, etoposide, and bleomycin, the other patient died of progressive disease despite intensive treatment with cisplatin and etoposide. Adjuvant therapy for Stage II germ cell tumors is not conventional treatment, and should be applied only in investigative settings where the long term effects and toxicity can be monitored, and does not reduce the need for frequent and thorough follow‐up of treated patients.