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Late multifocal gliomas in adolescents previously treated for acute lymphoblastic leukemia
Author(s) -
Fontana M.,
Stanton C.,
Pompili A.,
Amadori S.,
Mandelli F.,
Meloni G.,
Riccio A.,
Rubinstein L. J.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19871001)60:7<1510::aid-cncr2820600718>3.0.co;2-v
Subject(s) - medicine , methotrexate , lymphoblastic leukemia , context (archaeology) , leukemia , incidence (geometry) , radiation therapy , central nervous system , acute lymphocytic leukemia , oncology , pediatrics , paleontology , physics , optics , biology
Three of 37 adolescents in long‐term remission from childhood acute lymphoblastic leukemia (ALL) developed malignant multifocal gliomas several years after completing treatment that included central nervous system (CNS) prophylaxis with radiation (RT) and intrathecal methotrexate (IT‐MTX). No recurrence of the leukemia was evident when the CNS tumors were discovered. Seventeen other similar cases have been recorded. The occurrence of second malignancies is reviewed in the context of this development and of the oncogenic effects of radiation. It is probable that prolonged exposure to IT‐MTX may have had a synergistic effect with radiation in contributing to the unusual incidence of glial tumors in these patients.