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Nonneoplastic circulating sézary‐like cells in cutaneous T‐cell lymphoma. Ultrastructural, immunologic, and T‐cell receptor gene‐rearrangement studies
Author(s) -
Bendelac Albert,
Tj O'Connor Nigel,
Daniel MarieThérèse,
Boitard Christian,
Michel Catherine,
Laroche Liliane,
Lesavre Philippe,
Bach JeanFrançois
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870901)60:5<980::aid-cncr2820600511>3.0.co;2-9
Subject(s) - lymphoma , lymphoproliferative disorders , pathology , t cell , gene rearrangement , mycosis fungoides , cutaneous t cell lymphoma , biology , cell , cancer research , medicine , immunology , gene , immune system , genetics
Approximately 67% of peripheral blood lymphocytes in a case of nonmycosis fungoides‐type cutaneous T‐cell lymphoma, exhibited Sézary‐like changes. Immunotyping showed a helper phenotype with an abnormally faint expression of the T3 membrane antigen, while quantitative electron microscopic study was suggestive of neoplasia. However, T‐cell receptor gene study did not show any DNA rearrangement in Ficoll‐separated blood lymphocytes, whereas clonal T‐cell proliferation was simultaneously evidenced in cutaneous (non‐Sézary‐like) tumor cells. It is concluded that reactive nonneoplastic Sézary‐like cells may be present not only in various benign conditions, as previously known, but also in T‐cell lymphomas. This study provides further evidence for the nonspecificity of Sézary‐like changes, and stresses the utility of T‐cell receptor gene rearrangement study for diagnostic and prognostic procedures during the course of T‐cell lymphoproliferative disorders.