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Serum selenium and vitamin E concentrations in families of lung cancer patients
Author(s) -
Miyamoto Hiroshi,
Araya Yoshikazu,
Ito Masami,
Isobe Hiroshi,
Dosaka Hirotoshi,
Shimizu Toru,
Kishi Fujiya,
Yamamoto Isao,
Honma Hiroshi,
Kawakami Yoshikazu
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870901)60:5<1159::aid-cncr2820600539>3.0.co;2-q
Subject(s) - medicine , lung cancer , selenium , adenocarcinoma , vitamin e , cancer , gastroenterology , lung , vitamin , endocrinology , adenocarcinoma of the lung , physiology , antioxidant , biology , biochemistry , materials science , metallurgy
Whether or not serum selenium and vitamin E (alpha‐tocopherol) concentrations were changed was examined among healthy families of lung cancer patients. Family members as a whole (115 sons and daughters of 55 patients with primary lung cancer) were found to have a trend to lower serum selenium levels (0.116 ± SD 0.024 μg/ml, 0.05 < P < 0.1). Particularly among families of adenocarcinoma patients, the mean level was significantly lower (0.111 ± 0.019 μg/ml, P < 0.05) than that (0.122 ± 0.014 μg/ml) in age‐ratio matched controls who did not have cancer patients among their second‐degree relatives. Serum vitamin E levels (11.85 ± 2.85 μg/ml) were significantly lower among family members of adenocarcinoma patients than the controls (14.1 ± 3.1 μg/ml, P < 0.01). Serum selenium and vitamin E levels were significantly lower in lung cancer patients ( n = 37, mean age, 63.9 ± 11.2 yr) than in the controls ( P < 0.001). These data suggest that there are familial factors in serum selenium and vitamin E levels among families of lung cancer patients.