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Hepatocellular carcinoma in chinese males and females. Possible causes for the male predominance
Author(s) -
Lai ChingLung,
Gregory Peter B.,
Wu PuiChee,
Lok Anna S. F.,
Wong KaiPing,
Ng Matthew M. T.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870901)60:5<1107::aid-cncr2820600531>3.0.co;2-o
Subject(s) - medicine , hepatocellular carcinoma , cirrhosis , carcinoma , hepatitis b virus , hepatitis , gastroenterology , physiology , demography , virus , immunology , sociology
The male–female ratio in 186 hepatocellular carcinoma (HCC) Chinese patients was 5:1. The clinical presentation, biochemical parameters, and histologic findings were the same in both sexes except for a higher proportion of underlying cirrhosis ( P = 0.02), and spider naevi ( P = 0.04) in the men. There were also more smokers and alcohol drinkers among the men. Over 75% of both sexes were positive for the hepatitis B surface antigen. The possible contributory factors to the predominance of males to females in HCC included: the association with the hepatitis B virus, the higher proportion of male cirrhotics, smoking, and alcohol drinking. The survival probability for both sexes was equally poor; the median survival was 8 weeks for males and 10 weeks for females.