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T‐cell prolymphocytic leukemia with an unusual phenotype CD4 + CD8 +
Author(s) -
KluinNelemans Hanneke C.,
GmeligMeyling Frits H. J.,
Kootte Antoinette M. M.,
Den Ottolander Gerard J.,
Termijtelen Annemarie,
Kluin Philip M.,
Beverstock Geoffrey C.,
Brand Anneke
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870815)60:4<794::aid-cncr2820600415>3.0.co;2-r
Subject(s) - prolymphocytic leukemia , cytotoxic t cell , cd8 , antigen , immunology , white pulp , leukemia , t cell , medicine , epitope , pokeweed mitogen , t lymphocyte , t cell leukemia , biology , cancer research , microbiology and biotechnology , spleen , immune system , chronic lymphocytic leukemia , in vitro , genetics , peripheral blood mononuclear cell
A patient with T‐cell prolymphocytic leukemia (T‐PLL) is described. The outcome was poor, with death 8 months after diagnosis, despite several therapeutic interventions. The cells carried both CD4 and CD8 epitopes, but other thymocytic markers were absent. The spleen showed infiltration of CD4 + CD8 + prolymphocytes in the red pulp and in T‐cell‐dependent areas of the white pulp. Immunologic function studies revealed proliferation after stimulation with mitogens and even several antigens. However, in the mixed lymphocyte culture the T‐PLL cells did not proliferate. Cytotoxic T‐cells could not be induced. In T‐non‐T recombination experiments neither helper nor suppressor cell function was found for poke‐weed mitogen‐dependent plasmablast generation of normal B‐cells. Cytogenetically, many abnormalities were found. Among them, 14q+; absence of chromosomes 8, 11, and 22; and the presence of large marker chromosomes and fragments.