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Somatostatinoma of vater's papilla and of the minor papilla
Author(s) -
Stömmer Peter E.,
Stolte Manfred,
Seifert Erwin
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870715)60:2<232::aid-cncr2820600219>3.0.co;2-i
Subject(s) - major duodenal papilla , pathology , immunoperoxidase , psammoma body , stain , enteroendocrine cell , enolase , medicine , anatomy , staining , immunohistochemistry , endocrine system , hormone , antibody , immunology , monoclonal antibody
Two cases of somatostatinomas of the major and minor papilla are reported. The tumors were characterized by solid trabecular and tubular arrangements of tumor cells and in one case by the presence of microvilli and psammoma bodies. The tumor cells contain many amine precursor uptake and dicarboxylation (APUD)‐granules with a diameter of 300 to 500 nm and low electron density. Immunoperoxidase stain showed intense staining only for somatostatin and low density of neuron‐specific enolase. Those tumors either resulted from pluripotent endocrine cells or from D‐cells of the mucosa or glands of the papilla.