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Serum hyaluronate in malignant pleural mesothelioma
Author(s) -
Frebourg Thierry,
Lerebours Guy,
Delpech Bertrand,
Benhamou Daniel,
Bertrand Philippe,
Maingonnat Catherine,
Boutin Christian,
Nouvet Georges
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870615)59:12<2104::aid-cncr2820591224>3.0.co;2-i
Subject(s) - medicine , mesothelioma , malignancy , gastroenterology , pleural effusion , pleural disease , pathology , cancer , respiratory disease , lung
The diagnostic value of hyaluronate concentration in effusions of malignant mesothelioma has been extensively reported but no information is available about serum hyaluronate in patients with this cancer. Using a new enzymoimmunologic assay based on hyaluronate‐hyaluronectin interaction, serum levels of hyaluronate were measured in 16 patients with malignant pleural mesothelioma, 50 patients with other pleural effusions, and 94 healthy blood donors. The mean serum hyaluronate level in patients with mesothelioma (mean, 750 μg/l; range, 29 to 5833 μg/l) was significantly higher than in patients with other pleural effusions (mean, 56 μg/l; range, 4 to 137 μg/l) and than in blood donors (mean, 24 μg/l; range, 0 to 94 μg/l). Comparison of serum hyaluronate values observed in mesotheliomas with the clinical course of the disease suggests that serum hyaluronate might increase only at an advanced stage of the cancer. Therefore, serum hyaluronate determination has probably no clinical value for early detection of malignant mesothelioma, but might be useful to evaluate the clinical course of this malignancy.