Premium
Malignant histiocytosis. Complete remission in two pediatric patients
Author(s) -
Simon Julius H.,
Tebbi Cameron K.,
Freeman Arnold I.,
Green Daniel M.,
Brecher Martin L.,
Barcos Maurice
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870501)59:9<1566::aid-cncr2820590906>3.0.co;2-z
Subject(s) - medicine , prednisone , vincristine , cyclophosphamide , malignant histiocytosis , complete remission , chemotherapy , doxorubicin , regimen , surgery , spontaneous remission , pediatrics , oncology , pathology , histiocyte , alternative medicine
The experience with the treatment of malignant histiocytosis has been disappointing. Despite modest treatment success with a combination of cyclophosphamide, Adriamycin (doxorubicin), vincristine and prednisone, the overall prognosis remains poor. There are only a few reports of prolonged complete remissions in pediatric patients. The following report describes two children who have had long‐term remission with an aggressive combination chemotherapy program that included intrathecal prophylaxis. The chemotherapeutic regimen described merits further evaluation in a larger number of patients.