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Bizarre (pseudomalignant) granulation‐tissue reactions following ionizing‐radiation exposure a microscopic, immunohistochemical, and flow‐cytometric study
Author(s) -
Weidner Noel,
Askin Frederic B.,
Berthrong Morgan,
Hopkins Marbry B.,
Kute Timothy E.,
McGuirt Frederick W.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870415)59:8<1509::aid-cncr2820590820>3.0.co;2-5
Subject(s) - granulation tissue , pathology , medicine , vimentin , immunohistochemistry , atypia , larynx , stromal cell , granulation , ionizing radiation , anatomy , wound healing , irradiation , classical mechanics , physics , nuclear physics , immunology
Two patients developed extremely bizarre (pseudomalignant) granulation‐tissue reactions in the larynx and facial sinuses, following radiation therapy for carcinoma. Containing pleomorphic spindle cells and numerous (sometimes atypical) mitotic figures, both tumefactive lesions simulated high grade malignancies. While the pleomorphic cells contained vimentin immunoreactivity, they were nonreactive for low or high molecular weight keratin. Flowcytometric study of paraffin‐embedded tissues revealed DNA indexes of 0.75 and 1.0. Neither recurred locally nor spread distantly after therapy. Their granulation‐tissue growth pattern, and the presence of stromal and endothelial cells showing similar degrees of cytologic atypia were central to their recognition as benign. These findings show that severely atypical, sometimes aneuploid, granulation‐tissue reactions can occur following radiation exposure. Care should be taken not to misinterpret these lesions as malignant.