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Brain tumors after cranial irradiation for childhood acute lymphoblastic leukemia. A 13‐year experience from the Dana‐Farber cancer institute and the children's hospital
Author(s) -
Rimm Ilonna J.,
Li Frederick C.,
Tarbell Nancy J.,
Winston Ken R.,
Sallan Stephen E.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870415)59:8<1506::aid-cncr2820590819>3.0.co;2-p
Subject(s) - medicine , radiation therapy , central nervous system , lymphoblastic leukemia , prophylactic cranial irradiation , leukemia , cancer , acute lymphocytic leukemia , oncology , brain tumor , pathology , myocardial infarction , conventional pci
Brain tumors developed in two children after they had received cranial irradiation as central nervous system therapy for acute lymphoblastic leukemia. A review of the literature demonstrated an increased incidence of brain tumors in survivors of acute lymphoblastic leukemia who received central nervous system irradiation. Most of the brain tumors occurred within a decade after radiotherapy. Further data will be required to determine whether early post‐radiation brain tumors in patients with acute lymphoblastic leukemia are due to the central nervous system irradiation or to a genetic predisposition.