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Agreement rates and American‐Japanese pathologists' comparability of a modified working formulation for non‐Hodgkin's lymphomas an analysis of the cases collected for the fifth international workshop on chromosomes in leukemia‐lymphoma
Author(s) -
Nanba Koji,
Yamamoto Hisashi,
Kamada Nanao,
Kikuchi Masahiro,
Suchi Taizan,
Frizzera Glauco,
Berard Costan W.,
Shimamura Kayako,
Kaneko Yasuhiko,
Sakurai Masaharu
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870415)59:8<1463::aid-cncr2820590812>3.0.co;2-f
Subject(s) - medicine , comparability , working formulation , medical diagnosis , lymphoma , hodgkin lymphoma , medical physics , nuclear medicine , family medicine , radiology , pathology , non hodgkin's lymphoma , mathematics , combinatorics
Histopathologic slides of 368 cases collected from 16 institutions around the world for the Fifth International Chromosome Workshop were independently reviewed by a group of five hematopathologists consisting of two Americans and three Japanese. Agreement rates of their diagnoses using the Working Formulation (WF) for non‐Hodgkin's lymphomas were studied. A modified classification scheme of the WF was used in order to define cytologic subtypes more specifically, enabling 65 possible diagnostic choices. Data analyses by computer revealed that at least four out of five diagnostic agreements were observed in 290 cases (78.9%). Similar agreements were observed in more than 80% of the cases for most of the categories of the WF, excepting diffuse small cleaved (733%), diffuse mixed (64.2%), diffuse large cell (76.5%), and immunoblastic lymphoma (70.2%). Agreement rates between American and Japanese pathologists did not demonstrate statistically significant differences against expected values. It was concluded that the WF was a reliable and useful classification system for multi‐institutional as well as international projects, although refinements may be necessary in some categories for better diagnostic agreement.