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Immune hemolyitc anemia associated with streptococcal preparation OK‐432
Author(s) -
Nomura Shigeo,
Kanoh Tadashi
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870415)59:8<1409::aid-cncr2820590805>3.0.co;2-w
Subject(s) - medicine , immunopotentiator , autoimmune hemolytic anemia , immune system , anemia , concomitant , hemolytic anemia , immunology , coombs test , antibody , hemoglobin , gastroenterology
In the course of administration of an immunopotentiator, streptococcal agent OK‐432, a patient with lung cancer was found to have severe anemia and a strongly positive antiglobulin test. In the absence of the drug, eluates from the patient's erythrocytes reacted strongly by the indirect antiglobulin test with a panel of washed Group O erythrocyte samples. The eluated antibody was composed of monoclonal IgG1‐lambda. Upon discontinuing the drug the patient's hemoglobin level increased slowly with concomitant normalization of the reticulocyte count. Although very rare, drug‐induced immune hemolytic anemia should be included in the list of adverse effects of immunopotentiators. This is the first reported case of immune hemolytic anemia associated with OK‐432.