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Detection of SSEA‐1 on human renal tumors
Author(s) -
Liebert Monica,
Jaffe Ronald,
Taylor Rodney J.,
Ballou Byron T.,
Solter Davor,
Hakala Thomas R.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870415)59:8<1404::aid-cncr2820590804>3.0.co;2-d
Subject(s) - immunoperoxidase , renal cell carcinoma , pathology , monoclonal antibody , immunohistochemistry , medicine , staining , antigen , kidney , wilms' tumor , antibody , immunology
Stage‐specific embryonic antigen‐1 (SSEA‐1) was localized on paraffin embedded, formalin fixed specimens of human renal tumors by immunoperoxidase staining using a monoclonal antibody. Of 19 renal cell carcinoma (RCC) samples tested, 12 were positive for SSEA‐1; SSEA‐1 was also found on distinct elements in two samples of Wilms' tumor. No correlation was found between expression of SSEA‐1, and RCC morphology or pattern of growth. Because SSEA‐1 is found on proximal tubules in the normal kidney, these results support the hypothesis that RCC arises from the cells of the proximal tubule. Furthermore, since >60% of the RCCs examined expressed SSEA‐1, this antigen may prove to be a useful target for immunolocation or therapy of metastatic RCC.