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Occurrence of immunoblastic B‐cell lymphoma in hairy cell leukemia
Author(s) -
Arnalich F.,
Camacho J.,
Jimenez C.,
Lahoz C.,
Patrón M.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870315)59:6<1161::aid-cncr2820590621>3.0.co;2-6
Subject(s) - medicine , pathology , lymphoma , lymph node biopsy , asymptomatic , splenectomy , hairy cell leukemia , lymph node , biopsy , bone marrow , liver biopsy , infiltration (hvac) , leukemia , spleen , physics , thermodynamics
A 47‐year‐old man, was referred for evaluation of asymptomatic splenomegaly in September 1981, and a diagnosis of hairy cell leukemia (HCL) at the initial clinical stage was made. The patient remained asymptomatic until May 1985, when splenectomy was performed because of anemia and splenomegaly. Bone marrow and liver biopsy specimens showed diffuse infiltration by abnormal tartase resistant acid phosphatase (TRAP) positive lymphocytes with typical aspect of hairy cells. Four months later, he developed fever of unknown origin and, at laparotomy, diffuse retroperitoneal lymph node enlargement and metastatic liver nodules were seen. Lymph node and liver biopsy specimens showed diffuse infiltration by abnormal large lymphocytes, which bore monoclonal surface immunoglobulin M and light chain kappa. Only six cases of non‐Hodgkin's lymphoma associated with HCL have been published to date. This report describes an additional case of immunoblastic B‐cell lymphoma, preceded 4 years earlier by the diagnosis of HCL. Cancer 59:1161‐1164, 1987.