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High dose cyclophosphamide, BCNU, and VP‐16 (CBV) as a conditioning regimen for allogeneic bone marrow transplantation for patients with acute leukemia
Author(s) -
Zander Axel R.,
Culbert Steven,
Jagannath Sundar,
Spitzer Gary,
Keating Michael,
Larry Nanette,
Cockerill Kevin,
Hester Jeane,
Horwitz Leonard,
Vellekoop Lijda,
Swan Forrest,
McCredie Kenneth,
Dicke Karel A.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870315)59:6<1083::aid-cncr2820590606>3.0.co;2-p
Subject(s) - medicine , cyclophosphamide , etoposide , leukemia , transplantation , total body irradiation , surgery , regimen , acute leukemia , gastroenterology , chemotherapy , bone marrow , busulfan
A high dose combination chemotherapy regimen (CBV) consisting of cyclophosphamide (1.5 gm/m 2 day 1 to day 4); BCNU (300 mg/m 2 day 1) and etoposide (100 mg/m 2 every 12 hours for 6 doses), followed by bone marrow transplant from human leukocyte antigen (HLA) identical sibling donors, was evaluated in 29 patients in whom acute leukemia was in relapse or remission. Engraftment of donor cell type occurred in all but one of 21 patients, in whom marker differences between donor and recipient were established. Two of 11 patients transplanted during relapse of the disease, lived beyond 1 year after bone marrow transplantation. One patient died free of leukemia, 41 months after transplantation of meningitis. Two of seven patients transplanted during the second remission of the disease, are alive and free of leukemia at 42+, and 8+ months. All patients transplanted during the third or fourth remission of the disease have died from either a further relapse, or transplant related causes. The low incidence of organ toxicity with CBV allows for further dose escalation of its drug components. Cancer 59:1083‐1086, 1987.