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Characterization of immunologic function in homosexual men with persistent, generalized lymphadenopathy and acquired immune deficiency Syndrome
Author(s) -
Burkes Ronald L.,
Abo Wataru,
Levine Alexandra M.,
LinkerIsraeli Mariana,
Parker John W.,
Gill Parkash S.,
Krailo Mark,
Horwitz David A.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870215)59:4<731::aid-cncr2820590412>3.0.co;2-5
Subject(s) - medicine , immune system , immunology , pokeweed mitogen , cytotoxic t cell , antibody , asymptomatic , generalized lymphadenopathy , interleukin 2 , biology , peripheral blood mononuclear cell , lymphoma , biochemistry , in vitro
A syndrome of persistent, generalized lymphadenopathy (PGL), related to the acquired immune deficiency syndrome (AIDS), has been described in homosexual men. To further characterize and correlate the immunologic status of patients with PGL with those in AIDS, we studied spontaneous and pokeweed mitogen (PWM)‐induced IgG synthesis by B‐cells, T‐cell subsets in peripheral blood (PB), natural cytotoxicity (NC), and Interleukins (IL)‐1 and IL‐2 production in 39 homosexual patients (21 PGL 13 AIDS; five asymptomatic homosexual men), in whom 32 of 35 tested (91%) had antibodies to human T‐lymphotropic virus‐III (HTLV‐III). Cancer 59:731‐738, 1987. A profound abnormality in B‐cell function was found in AIDS and PGL, consisting of high spontaneous IgG production, with paradoxic suppression of IgG synthesis after PWM. IL‐2 values were more often low in AIDS when compared with PGL ( P < 0.001). The PB lymphocyte count was normal in PGL and reduced in AIDS ( P < 0.001). OKT4 ldquo;helper” cells were decreased in PGL, but even lower in AIDS ( P < 0.001), while OKT8 “cytotoxic/suppressor” cells were normal in AIDS and increased in PGL ( P < 0.01). The T4:T8 ratio was reversed in both, but more abnormal in AIDS ( P < 0.001). A decrease in NC killing was observed in AIDS when compared with heterosexual controls. Thus, patients with PGL and AIDS both demonstrate a spectrum of immunologic dysfunction, involving the cellular and humoral arms of the immune system.