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Thoracotomy for pulmonary metastatic osteosarcoma. An analysis of prognostic indicators of survival
Author(s) -
Meyer William H.,
Schell Michael J.,
Kumar A. P. Mahesh,
Rao Bhaskar N.,
Green Alexander A.,
Champion John,
Pratt Charles B.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870115)59:2<374::aid-cncr2820590235>3.0.co;2-6
Subject(s) - medicine , thoracotomy , osteosarcoma , univariate analysis , proportional hazards model , surgery , survival analysis , radiology , oncology , multivariate analysis , pathology
Removal of pulmonary metastases of osteosarcoma by thoracotomy is an accepted treatment; however, few investigators have analyzed the value of various prognostic factors in estimating survival. A review of all patients undergoing thoracotomy for recurrent osteosarcoma with pulmonary metastases treated at St. Jude Children's Research Hospital is reported. Since 1968, two thirds (39/59) of all patients who developed pulmonary metastases have had a total of 66 thoracotomies. Nine patients are alive with no evidence of disease, and six additional patients are alive with disease. Analyzed in 39 evaluable patients, the prognostic factors that correlate with survival by univariate analysis are: sex, number of nodules detected radiographically and resected, completeness of resection, and tumor location (bilateral versus unilateral). By Cox regression analysis, only sex and the number of nodules detected either radiographically or during surgery, and resected, had statistically significant correlation with survival. Thoracotomy is curative for some patients with pulmonary metastatic osteosarcoma and Prognostic factors predictive for survival are defined. Cancer 59:374–379, 1987.