Premium
The spectrum of metabolic bone disease in lymphoblastic leukemia
Author(s) -
Cohn Susan L.,
Morgan Elaine R.,
Mallette Lawrence E.
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870115)59:2<346::aid-cncr2820590230>3.0.co;2-i
Subject(s) - medicine , radioimmunoassay , osteopenia , parathyroid hormone , endocrinology , bone resorption , alkaline phosphatase , osteoporosis , resorption , bone disease , bone mineral , calcium , enzyme , biochemistry , chemistry
Eight patients with childhood acute lymphoblastic leukemia (ALL) and hypercalcemia, osteopenia, or vertebral compression fractures seen at our institution during the last 12 years were evaluated for biochemical evidence of bone disease. Five patients were hypercalcemic, three had abnormal phosphorous levels, and four had elevated alkaline phosphatase values. Parathyroid hormone (PTH) was measured by a polyvalent radioimmunoassay in five patients and these levels were abnormally high in three patients. Four of these five patients also had PTH measured by a midregion‐specific radioimmunoassay. One patient had a high PTH value. Two patients had low levels and one patient had a normal PTH level. Although these studies suggest diverse biochemical mechanisms may be contributing to the bone changes and hypercalcemia seen in childhood ALL, ectopic PTH production as well as ectopically produced fragments of PTH may have a role in mediating bone resorption and hypercalcemia. Cancer 59:346–350, 1987.