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Fatal cardiac toxicity in bone marrow transplant patients receiving cytosine arabinoside, cyclophosphamide, and total body irradiation
Author(s) -
Trigg Michael E.,
Finlay Jonathon L.,
Bozdech Marek,
Gilbert Enid
Publication year - 1987
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19870101)59:1<38::aid-cncr2820590112>3.0.co;2-t
Subject(s) - medicine , cyclophosphamide , toxicity , total body irradiation , bone marrow , cardiac toxicity , chemotherapy , bone marrow suppression , pharmacology , oncology
Three patients developed fatal cardiac toxicity from the combination of cytosine arabinoside, cyclophosphamide, and total body irradiation while undergoing preparation for a bone marrow transplant. The pattern of the toxicity was unique for this combination of ablative chemotherapy. All three patients had autopsies demonstrating characteristic myocardial and pericardial toxicity. The cardiotoxic effects of this combination may be averted by lowering the dose of the cyclophosphamide. Cancer 59:38–42, 1987.