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T‐Cell lymphoma revealed by a peripheral neuropathy: A report of two cases with an immunohistologic study on lymph node and nerve biopsies
Author(s) -
Gherardi Romain,
Gaulard Philippe,
Prost Catherine,
Rocha Dario,
Imbert Michelle,
Andre Chantel,
Rochant Henri,
Farcet Jean Pierre
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861215)58:12<2710::aid-cncr2820581226>3.0.co;2-d
Subject(s) - medicine , lymphoma , pathology , lymph node , peripheral neuropathy , peripheral t cell lymphoma , immunology , t cell , immune system , endocrinology , diabetes mellitus
In two patients a peripheral neuropathy was the presenting symptom of a noncutaneous peripheral T‐cell lymphoma. In the first patient, the neuropathy had a relapsing and remitting course, the symptoms improved under corticosteroid therapy. The second patient suffered from a relentless neuropathy. In both cases the lymphoma infiltrated the peroneal nerve with an angiocentric and perivascular pattern resembling that observed in central nervous system lymphomas. The characterization of T‐cell subsets in the lymph node showed cells with the helper/inducer and suppressor/cytotoxic phenotype in the first case and a predominance of cells with the helper/inducer phenotype in the second case. In the nerve, lymphocytes beared the helper/inducer phenotype antigen. A typical paraneoplastic vasculitis of nerve showed clearly different immunologic features.