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Tuberculosis‐associated hemophagocytic syndrome: A systemic process
Author(s) -
Campo Elias,
Condom Enric,
Miro MariaJose,
Cid MariaCinta,
Romagosa Vicente
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861215)58:12<2640::aid-cncr2820581216>3.0.co;2-e
Subject(s) - hemophagocytosis , medicine , histiocyte , autopsy , tuberculosis , sepsis , malignant histiocytosis , pathology , immunology , bone marrow , pancytopenia
Virus‐associated hemophagocytic syndrome has been recently identified as a benign, reactive histiocytic proliferation distinct from Rappaport's malignant hystiocytosis. Other etiologic agents, including different bacteria, have also been identified. Three autopsy cases of hemophagocytic syndrome associated to acute tuberculous sepsis are presented. Benign histiocytic proliferation with striking hemophagocytosis was present in a disseminated, multisystemic pattern in all three cases. A relationship between systemic histiocytic proliferation and an anergic status in these patients is suggested.