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Diagnostic accuracy of fibronectin in the differential diagnosis of ascites
Author(s) -
Colli Agostino,
Buccino Guglielmo,
Cocciolo Massimo,
Parravicini Roberto,
Mariani Fiorella,
Scaltrini Giancarlo
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861201)58:11<2489::aid-cncr2820581123>3.0.co;2-8
Subject(s) - ascites , medicine , cirrhosis , gastroenterology , lactate dehydrogenase , differential diagnosis , hepatocellular carcinoma , pathology , cytology , fibronectin , carcinoma , enzyme , biology , cell , biochemistry , genetics
To evaluate the diagnostic accuracy of fibronectin levels in ascites to differentiate malignant from non‐malignant ascites, the authors studied 30 patients with sterile uncomplicated ascites in chronic liver disease, 18 patients with malignant ascites and four patients with spontaneous bacterial peritonitis. Fibronectin concentration was significantly higher in malignant ascites than in sterile ascites ( P < 0.001). High values ( > 85 mg/l) were found in four of six cases of hepatocellular carcinoma in liver cirrhosis with negative cytologic examination, and in six of seven peritoneal carcinomatoses. Low values (<85 mg/l) were found in four patients with liver metastases and in one patient with intrahepatic biliary duct carcinoma in cirrhosis. In four patients with infected ascites, the fibronectin level was low. Among all other parameters (total protein concentration, lactate dehydrogenase, gamma‐glutamyl‐transpeptidase, pH, amyiase, triglycerides, leukocyte count, and cytologic examination), fibronectin yielded the best degree of discrimination (diagnostic accuracy, 79%).