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Flow cytometric DNA analysis of neuroblastoma. Correlation with histology and clinical outcome
Author(s) -
Gansler Ted,
Chatten Jane,
Varello Michael,
Bunin Greta R.,
Atkinson BARBARA
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861201)58:11<2453::aid-cncr2820581117>3.0.co;2-i
Subject(s) - neuroblastoma , medicine , histology , pathology , grading (engineering) , ganglion , flow cytometry , stage (stratigraphy) , cell culture , biology , immunology , anatomy , ecology , genetics , paleontology
Clinical and histologic features of 38 cases of neuroblastoma were compared with data obtained by flow cytometric DNA analysis. Favorable clinical outcome was associated with an aneuploid stem line ( P < 0.01) and a low percentage of tumor cells in the S, G 2 , and M phases of the cell cycle ( P < 0.005). These favorable cytometric features were also associated with a favorable clinical stage (1, 2, 4s), and histologic evidence of Schwann's cell and ganglion cell differentiation. Consideration of cytometric data improved the sensitivity, specificity, and predictive efficiency of a current system for histologic grading of neuroblastoma.