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Elevated levels of a somatomedin‐binding protein PP12 in patients with ovarian cancer
Author(s) -
Iino Koichi,
Seppälä Markku,
Hein Pentti K.,
Sipponen Pentti,
Rutanen EevaMarja
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861115)58:10<2294::aid-cncr2820581023>3.0.co;2-q
Subject(s) - medicine , radioimmunoassay , somatomedin , ovarian cancer , cancer , endocrinology , ovary , gastroenterology , growth factor , receptor
The circulating levels of placental protein 12 (PP12), a somatomedin‐binding protein, were measured by radioimmunoassay in 37 postmenopausal women with ovarian tumors. Elevated levels (above 47 μg/1) were observed in 16 of 25 patients (64%) with malignant and 2 of 12 patients (17%) with benign tumors. Elevated levels were more frequent and higher in patients with advanced disease. Within 1 week of surgery, the levels fell in 13 of 17 cases (77%). In addition to clinical interest, these results contribute to our knowledge of carrier proteins of growth factors in patients bearing malignant ovarian neoplasms.