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Expression of epidermal growth factor receptors in human lung tumors
Author(s) -
Hwang David L.,
Tay Yeechaw,
Lin Shu S.,
LevRan Arye
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861115)58:10<2260::aid-cncr2820581017>3.0.co;2-u
Subject(s) - medicine , epidermal growth factor , receptor , epidermal growth factor receptor , lung , growth factor receptor inhibitor , cancer research , pathology
Using the adjacent historically normal tissues obtained from the same patients as controls, six human lung tumors were studied for the activities of epidermal growth factor (EGF) receptor binding, and receptor autophosphorylation. There was a 1.2‐ to 2.8‐fold increase in EGF receptor activities in lung tumors due to an increase in the number of receptors without changes in their affinity. The increase had no direct correlation with the degree of differentiation or the type of lung tumors. The elevated expression of EGF receptor may be one of the characteristics in lung tumors. Epidermal growth factor and its receptor also may play a role in the regulatory mechanisms during tumorigenesis.