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The long‐term effect of cisplatin on renal function
Author(s) -
Fjeldborg Paul,
Sørensen Jesper,
Helkær Poul E.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861115)58:10<2214::aid-cncr2820581009>3.0.co;2-i
Subject(s) - medicine , renal function , urology , cisplatin , effective renal plasma flow , testicular cancer , creatinine , urinary system , diuresis , chemotherapy , endocrinology , nephrotoxicity , kidney , renal blood flow
The long‐term effect of cisplatin on renal function was studied in a follow‐up investigation, 16 to 52 months after chemotherapy in 22 patients with disseminated nonseminomatous testicular cancer. The median cumulated cisplatin dose was 452 mg/in 2 (range, 275–650 mg/m 2 ). Prehydration with isotonic saline secured diuresis above 100 ml/hour. GFR (glomerular filtration rate: 51 Cr‐EDTA clearance) fell by 12.5% (median, P < 0.01) compared with the pretreatment level. Effective renal plasma flow ( 125 I‐hippuran clearance) was estimated to be likewise reduced. The serum creatinine level rose 8 μmol/1 (median, P < 0.05) during the treatment period with no further rise afterwards. Serum magnesium and urinary excretion of beta‐2‐microglobulin were normal. The results indicate a moderate and permanent reduction in GFR with no signs of long‐term tubular defects in patients treated with cisplatin.