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Starch microsphere‐induced arterial flow redistribution after occlusion of replaced hepatic arteries in patients with liver metastases
Author(s) -
Civalleri Dario,
Scopinaro Gianni,
Simoni Gianantonio,
Claudiani Franco,
Repetto Marina,
Decian Franco,
Bonalumi Umberto
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861101)58:9<2151::aid-cncr2820580932>3.0.co;2-f
Subject(s) - medicine , perfusion , ligation , occlusion , catheter , artery , blood flow , microsphere , radiology , ischemia , gastroduodenal artery , nuclear medicine , chemical engineering , engineering
In four patients with major anomalies of the hepatic artery undergoing intra‐arterial chemotherapy, aberrant lobar vessels were ligated and catheters were inserted into the contralateral artery. Catheter perfusion scans performed early after ligation with 99m Tc‐macroaggregated albumin (MAA) showed a defective perfusion of the lobe supplied by the occluded artery (0.43, 0.23, 0.11, and 0.28, respectively, as compared to the contralateral lobe). Further MAA scans performed after catheter infusion of 90,000,000 parts of degradable starch microspheres (DSM) showed a near normal perfusion of the ischemic lobe (0.91, 0.96, 0.87, and 0.98). On the contrary, simple MAA scans performed in the first two patients 114 and 135 days after ligation showed a still defective arterial perfusion of the ischemic lobe (0.60, and 0.24). The DSM‐induced redistribution of flow towards ischemic portions of the liver suggests a possible new role of DSM in regional treatment of liver tumors in cases with either occlusion of aberrant vessels or “hypovascular” tumors.