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Peanut lectin binding in breast carcinoma: Lack of correlation with estrogen receptor content
Author(s) -
Stanley Michael W.,
Kiang David T.,
Sibley Richard K.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861101)58:9<2046::aid-cncr2820580915>3.0.co;2-y
Subject(s) - peanut agglutinin , estrogen receptor , immunoperoxidase , lectin , breast carcinoma , estrogen , medicine , endocrinology , antigen , staining , hormone , agglutinin , immunohistochemistry , breast cancer , pathology , antibody , cancer , immunology , monoclonal antibody
Previous reports have shown binding of peanut agglutinin (PNA) by immunoperoxidase techniques in normal, benign proliferative, and malignant breast epithelia. Correlation of binding with maturity, secretory activity, hormonal milieu, and tissue hormone receptor content has been described. To investigate the relationship between PNA staining by the avidin‐biotin complex technique and estrogen receptor (ER) content, 79 breast tumors of different types and known tissue ER content were studied. Thirty‐eight of 50 ER‐positive cases were PNA‐positive. Twenty of 29 ER‐negative cases were PNA‐positive. Statistical analysis shows the two factors to be independent (0.5 < P < 0.9). The literature on blood group antigens in breast carcinoma and histochemical applications of PNA is reviewed.