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Bronchiolocentric chronic lymphocytic leukemia
Author(s) -
Palosaari David E.,
Colby Thomas V.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861015)58:8<1695::aid-cncr2820580819>3.0.co;2-y
Subject(s) - medicine , chronic lymphocytic leukemia , pathology , lung , parenchyma , auscultation , leukemia , immunology
Three patients presented with symptoms of severe dyspnea, radiologic evidence of bilateral pulmonary infiltrates, and one had diffuse wheezing on auscultation. Open‐lung biopsies revealed a neoplastic lym‐phocytic infiltrate in an exquisitely bronchiolocentric distribution with relative sparing of the rest of the lung parenchyma. Two patients had a history of chronic lymphocytic leukemia (CLL), whereas pulmonary disease was the initial manifestation of the lymphoproliferative disorder in the third. Clinical and pathologic features of the three cases are discussed.