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Retreatment of pediatric brain tumors with radiation and misonidazole: Results of a CCSG/RTOG phase I/II study
Author(s) -
Wara William M.,
Wallner Kent E.,
Levin Victor A.,
Liu HsiuChih,
Edwards Michael S. B.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861015)58:8<1636::aid-cncr2820580810>3.0.co;2-r
Subject(s) - medicine , misonidazole , vomiting , nausea , toxicity , chemotherapy , radiation therapy , surgery , nuclear medicine , biochemistry , chemistry , in vitro
Twenty‐nine patients with recurrent pediatric brain tumors after full‐dose treatment with radiation were retreated with misonidazole (9 gm/m 2 ) and whole‐brain irradiation (300 rad × 10). Seventeen of 29 patients (59%) experienced nausea and vomiting with misonidazole administration and 6 patients (21%) developed peripheral neuropathy. Serum levels of misonidazole were similar to those reported for adults. One patient died of trauma shortly after retreatment. For the remaining 28 patients, the median time‐to‐progression was 5.5 months. Median survival was 13 months. Six patients (21%) developed radiation toxicity, two of whom died from the toxicity. Whereas the results on this study are similar to reported series of patients receiving salvage chemotherapy for recurrent pediatric brain tumors, more effective treatment clearlv is needed.