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Fatal necrosis of the liver during ABVD chemotherapy for Hodgkin's disease: A case report
Author(s) -
Joensuu Heikki,
Söderström Karlove,
Nikkanen Väinämö
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861001)58:7<1437::aid-cncr2820580710>3.0.co;2-a
Subject(s) - medicine , abvd , vinblastine , dacarbazine , necrosis , bleomycin , chemotherapy , gastroenterology , pathology , vincristine , cyclophosphamide
A case of massive fatal liver necrosis during chemotherapy for stage IVA Hodgkin's disease is described. A previously healthy 50‐year‐old male was given doxorubicin 25 mg/m 2 , bleomycin 10 mg/m 2 and vinblastine 6 mg/m 2 on days 1 and 14 of the cycle combined with dacarbazine 150 mg/m 2 on days 1–5 (ABVD) with 4‐week intervals. During the fourth cycle of chemotherapy the patient developed fatal liver necrosis with anuria and uncontrolled bleeding. At autopsy, 80% of the liver was necrotic and viable cells were seen only in periportal areas. Dacarbazine may have caused the necrosis. Liver necrosis caused by drugs should be considered if unexplained hepatomegaly and a rise in serum liver enzyme levels is noted during ABVD treatment.