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The effect of tamoxifen therapy on thyroid function tests
Author(s) -
Gordon Derek,
Beastall Graham H.,
McArdle Colin S.,
Thomson John A.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19861001)58:7<1422::aid-cncr2820580707>3.0.co;2-6
Subject(s) - medicine , tamoxifen , endocrinology , globulin , thyroid function , breast cancer , serum concentration , thyroid , thyroxine binding globulin , statistical significance , hormone , thyroid function tests , triiodothyronine , cancer
Serum tri‐iodothyronine (T 3 ), thyroxine (T 4 ) and thyroid‐stimulating hormone (TSH) concentrations were measured in 50 postmenopausal patients with breast cancer receiving tamoxifen therapy. Ten patients (20%) showed an elevation of serum total T 4 concentrations and two of these patients showed additional elevation of serum total T 3 levels. One patient had a persistently raised free T 4 concentration and was considered to be thyrotoxic. Serum thyroxine‐binding globulin (TBG) was estimated in six patients with elevated total T 4 concentrations and was found to be raised in each case. Total serum T 4 concentrations rose in seven of ten additional patients after starting tamoxifen therapy. However this change did not reach statistical significance. This trend in serum T 4 concentrations was not shown in ten normal volunteers taking tamoxifen for 1 week.