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Immunocytochemical evidence for gastric proteases in adenocarcinoma of the stomach
Author(s) -
Warner Thomas F.,
Donnelly William J.,
Reza Hafez G.,
Renwick Barbara,
Engstrand David,
Barsness Lona
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860915)58:6<1328::aid-cncr2820580624>3.0.co;2-0
Subject(s) - histogenesis , intestinal metaplasia , pathology , medicine , adenocarcinoma , stomach , gastric mucosa , pepsin , foveolar cell , lymph node , mucus , staining , carcinoma , metaplasia , cancer , immunohistochemistry , biology , enzyme , ecology , biochemistry
When anti‐sera to bovine pepsinogen and chymosin (rennin) was used, immunoreactive tumor cells were found in 12 of 23 gastric adenocarcinomas irrespective of the tumor subtype, degree of differentiation, or the presence or absence of intestinal metaplasia in the adjacent gastric mucosa. Nine of ten lymph node metastases contained immunoreactive tumor cells. Except for focal positively staining acini in Brunner' s glands the antibodies did not stain normal small intestine or areas of intestinal metaplasia. Although intestinal metaplasia is a predisposing factor in gastric carcinoma it may be irrelevant to its histogenesis and differentiation. Instead, the mucus neck cells, being the stem cells of the normal gastric mucosa, may be the target of malignant transformation in gastric carcinoma.