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Reactive histiocytosis in acute lymphoblastic leukemia and non‐hodgkin' s lymphoma
Author(s) -
Liang DerCherng,
Chu Marie Lin,
Shih ChiChing
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860915)58:6<1289::aid-cncr2820580619>3.0.co;2-h
Subject(s) - malignant histiocytosis , medicine , lymphoma , histiocyte , histiocytosis , pathogenesis , pathology , leukemia , immunology , cancer research , disease
An extensive hemophagocytic syndrome in the termination of one case of pre‐T acute lymphoblastic leukemia (ALL) and another case of non‐Hodgkin' s lymphoma (NHL), are described. Since most of the proliferating cells were mature macrophages and these cells were limited in the mononuclear phagocytic system (MPS), it was determined to be a reactive histiocytosis rather than histiocytic medullary reticulosis (HMR) or malignant histiocytosis (MH). The pathogenesis of the HMR or MH‐like syndrome in these patients is discussed, and it is considered that this might be a reaction of the bacterial sepsis related to their immunosuppressed state secondary to the pre‐existing malignancies and/or the cytotoxic therapy. The literature was reviewed. Based on a proposal for differential diagnosis between reactive histiocytosis and MH (or HMR), the heterogeneity of HMR‐like syndrome complicating the malignancies are clarified.