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Chordoma and malignant fibrous histiocytoma.Evidence for transformation
Author(s) -
Belza Mark G.,
Urich Henry
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860901)58:5<1082::aid-cncr2820580517>3.0.co;2-u
Subject(s) - chordoma , medicine , malignant transformation , pathology , sarcoma , biopsy
Serial biopsy specimens of a histologically proven cervical chordoma in a 57‐year‐old woman taken at intervals over a 7‐year period, demonstrate a progression and complete transformation to a malignant fibrous histiocytoma 5 years following radiation therapy. Intermediate spindle‐shaped cells demonstrating keratin positivity were discovered, lending credence to the theory of cellular transformation. Additionally, a fine reticulin network was noted around the chordoma cells. A review of the literature is undertaken chronicling the documented associations of chordoma and sarcoma, followed by a discussion of the various causes proposed to explain this phenomenon. Cancer 58:1082‐1087, 1986.