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Hypercoagulable state induced by cytostatic drugs in stage ii breast cancer patients
Author(s) -
Canobbio Luciano,
Fassio Tiziana,
Ardizzoni Andrea,
Bruzzi Paolo,
Queirolo Maria Antonietta,
Zarcone Daniela,
Giorgio Flavia DL,
Rosso Riccardo,
Santi Leonardo
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860901)58:5<1032::aid-cncr2820580509>3.0.co;2-u
Subject(s) - medicine , chemotherapy , breast cancer , cancer , thrombosis , coagulation , platelet , stage (stratigraphy) , incidence (geometry) , adjuvant chemotherapy , oncology , adjuvant , surgery , paleontology , physics , optics , biology
An increased incidence of thromboembolic complications occurring in cancer patients during chemotherapy was recently reported. In view of this report, a study in 49 patients receiving adjuvant chemotherapy for Stage II breast cancer was begun in order to determine the effect of antineoplastic drugs on coagulation factors and platelet function. Among the coagulation factors, a significant decrease of thrombin time and partial prothrombin time was observed, whereas platelet function tests were unchanged. This finding suggests a trend towards hypercoagulability induced by chemotherapy. This effect should be considered when chemotherapy is employed in advanced cancer patients at high risk for thrombosis. Cancer 58:1032‐1036, 1986.