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Further studies on the therapeutic effect of indomethacin on esophageal tumors
Author(s) -
Rubio Carlos A.
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860901)58:5<1029::aid-cncr2820580508>3.0.co;2-d
Subject(s) - medicine , gastroenterology , esophageal cancer , drug , esophagus , pharmacology , cancer
The effect of treatment with the nonsteroid anti‐inflammatory drug indomethacin, was investigated in 250 3‐month‐old C57B1 female mice following induction of esophageal tumors with diethylnitrosamine (DEN). Already 3 months after DEN treatment, many esophageal tumors were committed to occur: despite discontinued DEN treatment, the number of tumors had increased significantly at 6 or 9 months of observation. Following 3 and 4 months of DEN administration, the development of many already committed esophageal tumors was significantly abrogated by treating the mice with indomethacin. Cancer 58:1029‐1031, 1986.