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Peripheral neuropathy associated with high‐dose ara‐C therapy
Author(s) -
Borgeat Alain,
Stalder Michelle,
De Muralt Benoit
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860815)58:4<852::aid-cncr2820580408>3.0.co;2-i
Subject(s) - medicine , polyneuropathy , peripheral neuropathy , peripheral , toxicity , axonal degeneration , peripheral nervous system , myelin , central nervous system , pathology , gastroenterology , surgery , endocrinology , diabetes mellitus
Central nervous system toxicity associated with high‐dose cytosine arabinoside (Ara‐C) therapy (HD Ara‐C) is well known. The authors report the case of a severe isolated peripheral polyneuropathy due to HD Ara‐C. Electrophysiologic changes and histologic observations were consistent with axonal degeneration and scattered destruction of myelin sheaths. This observation emphasizes the need for careful complete neurologic evaluation for patients receiving HD Ara‐C treatment.