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Indium 111‐labeled platelet kinetic studies and platelet‐ associated igg in hairy cell leukemia
Author(s) -
Panzer Simon,
Lechner Klaus,
Neumann Erich,
Meryn Siegfried,
Haubenstock Alexander
Publication year - 1986
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(19860715)58:2<234::aid-cncr2820580206>3.0.co;2-e
Subject(s) - platelet , medicine , immunology , leukemia , hairy cell leukemia , gastroenterology
In order to study the pathogenesis of thrombocytopenia in patients with hairy cell leukemia (HCL), levels of platelet‐associated IgG (PAIgG), platelet life span (MLS), and the sequestration site of autologous 111 In‐labeled platelets were measured in nine patients with HCL. Splenectomized patients (n = 4) had a higher platelet count (x = 122.5 × 10 9 /1; range, 80–190 × 10 9 /1) as well as higher levels of PAIgG (x = 10.7%; range, 5.8–16.9%), than nonsplenectomized patients (platelets x = 76 × 10 9 /1, range 40–100 X 10 9 /1; PAIgG x = 3.2%, range 2.2–4.2%). A normal recovery of 111 in‐labeled platelets was found in Splenectomized patients, whereas a very low recovery was observed in the nonsplenectomized group (x = 70.2%, range, 50–82.5%, versus x = 22.4%, range, 15–28.2%). The MLS was borderline normal in all patients. The site of sequestration was the spleen in nonsplenectomized patients. The low recovery of 111 In‐labeled platelets in nonsplenectomized patients suggests “hypersplenism” with pooling as a major cause of thrombocytopenia, in addition to impaired thrombocytopoiesis and possible immune‐mediated platelet destruction. Cancer 58:234–237, 1986.